Her father has been a strong supporter in her music career, penning many songs that became Thanh Lam's hits: Khát Vọng (Desire), Tình Yêu Không Lời (Wordless Love), Màu Hoa Đỏ (Color of Rose).

She has produced more than thirty albums to date, collaborating with such prominent Vietnamese composers and singers as Thanh Tùng, Dương Thụ, Lê Minh Sơn and singers Trần Thu Hà, Mỹ Linh, Hồng Nhung, Tùng Dương, and most recently, Trọng Tấn.

She has worked with the Vietnamese-Danish jazz musician Niels Lan Doky on several music projects, notably the Vong Nguyet (Wishing Upon the Moon) show at the Roskilde Festival in 2006 and 2007.

Songwriter Thuan Yen used to share about this trip as: "She was on stage playing guitar and singing the song Mat Troi va Anh Lua of Tran Long An.

Besides, from 1985 to 1991, she was also the member of National's Music Crew and had many performances at many different countries: Germany, Russia, Bulgaria, China, Cuba, Netherlands, Hungary and Romania.

In 1993, Phuong Dong (with Thanh Lam as main vocal) won first prize of 1st National Ballad Music Band Festival which was held in Da Nang in August.

Songwriter Duong Thu shared his opinion about his favorite performance of the night as: "In this show, Thanh Lam sang the song "Bai Hat Cho Anh" on the remix of Quoc Trung which was really touching.

All of her songs that helped her won the awards as: Khat Vong, Cho Em Mot Ngay, Ben Em La Bien Rong, Giot Nang Ben Them, Hoa Tim Ngoai San, Em Va Toi, Chia Tay Hoang Hon, Mot Ngay Mua Dong, Chieu Xuan, Hoa Co Mua Xuan, Hat Voi Chu Ve Con, Ngoi Hat Ca Benh Bong, Khong The Va Co The, Doi Cho, Do Tinh,... Thanh Lam was married to composer Quốc Trung[2] from 1994 to 2004; the couple has two children.