[6] With its prominent electric guitar line, "That Lady" helped establish Ernie Isley as a powerhouse performer.
[8] "That Lady" is sampled in "A Year and a Day," a section in the "B-Boy Bouillabaisse" suite on the 1989 Beastie Boys album Paul's Boutique.
"That Lady" is sampled in "Jus 1 Kiss (The Isley Bootleg)" by Basement Jaxx, which was released in 2001 and appeared on their 2005 greatest hits compilation The Singles.
Re-recorded elements of "That Lady" are incorporated in "i", the lead single of Kendrick Lamar's 2015 album To Pimp a Butterfly.
[9] "That Lady" appears in the 2004 film Anchorman: The Legend of Ron Burgundy, introducing Christina Applegate's character, the news anchor Veronica Corningstone, when she first arrives at the San Diego television station KVWN Channel 4.