Since 2012, she has been presenting in notable talk show program called Khit Thit Pyo May (Girls in New Era).

[9][11] Thanzin Nwe Win also acted in many TV commercials including MPT, Yo Yar Hin Noodle, Happy Coffee, Ready sardine.

[12] Following the 2021 Myanmar coup d'état, Thazin Nwe Win was active in the anti-coup movement both in person at rallies and through social media.

[13][14] On 5 April 2021, warrants for her arrest were issued under section 505 (a) of the penal code by the State Administration Council for speaking out against the military coup.

Along with several other celebrities, she was charged with calling for participation in the Civil Disobedience Movement (CDM) and damaging the state's ability to govern, with supporting the Committee Representing Pyidaungsu Hluttaw, and with generally inciting the people to disturb the peace and stability of the nation.