[7] A high-school dropout who was bullied for her gender-nonconforming appearance,[8] Stamper started her career in the late 1990s, selling mixtapes by underground DJs at raves.

[12] Historically, Stamper defended the use of The Black Madonna, citing her Catholic faith as a reason for her attachment to the icon.

[13] However, in response to a Change.org petition that raised concerns of racial insensitivity, Stamper changed her stage name to The Blessed Madonna on July 20, 2020.

"[14] On July 27, 2020, British singer Dua Lipa announced the release of a remix by Stamper of her song "Levitating" featuring American artists Madonna and Missy Elliott to serve as the fifth single of her 2020 album, Future Nostalgia.

In 2022, Stamper released the single "Serotonin Moonbeams" which featured vocals from singer Uffie, as well as a sample from Burton Inc.'s "Why Don't You Let Me Know".