In an attempt to emulate Rand, who worked for several years as a screenwriter, Anna moves to Los Angeles and attempts to write a television sitcom featuring an animal character named "Ayn Ram".

After falling behind on her TV writing and becoming addicted to Adderall, Anna abandons Rand's ideas.

In a review for The New Yorker, Katy Waldman compares The Book of Ayn to the earlier novel Two Girls, Fat and Thin by Mary Gaitskill, which focuses on a woman who follows a Rand-like character.

[1] In The Washington Post, Maddie Crum praises Freiman's skill for writing comedy.

[2] In the Los Angeles Times, Ryan Chapman calls the book "one of the funniest and unruliest novels in ages".