Although the company first operated only two years before the start of The Great Depression, it was initially very prosperous due to innovative advertising promoted by its owner, Ernest Morgan Oswalt.

Oswalt hired writer Florence Ward to create a radio variety show that would feature commercials for the company.

The company's treasurer and Oswalt's nephew, I. Willard Crull, would write over a hundred radio plays for the program under the pen name Anthony Wayne.

Its Wednesday night time slot was eight p.m., which had it competing against NBC's Four Star Revue and CBS's Arthur Godfrey and His Friends (a program that had already "shot to the top of the TV ratings and stayed there for several years").

At this time, an adage was added to the English lexicon, "To work at Campana is like being a member of Frederick Stock's musical ensemble".

[5] By the late 1940s, I. Willard Crull (he had been president since 1942 but spent more time developing perfume lines) took full rein of Campana.