Historically, lotions also had an advantage in that they may be spread thinly compared to a cream or ointment and may economically cover a large area of skin, but product research has steadily eroded this distinction.
[5] A 2006 study found that application of hospital-grade lotion after hand washing significantly reduced skin roughness and dryness.
[6][failed verification] Care must be taken not to use consumer lotions in a hospital environment, as the perfumes and allergens may be a danger to those who are immunodeficient or with allergies.
Various other ingredients such as fragrances, glycerol, petroleum jelly, dyes, preservatives, proteins and stabilizing agents are commonly added to lotions.
[13] Those with eczema are especially vulnerable to an allergic reaction with lotion, as their compromised skin barrier allows preservatives to bind with and activate immune cells.
[12] A 2021 study found that "frequent skin moisturization in early life might promote the development of food allergy, most likely through transcutaneous sensitization".