The Chameleon Club was a music venue located in the historic downtown Lancaster, Pennsylvania.

Founded by Rich Ruoff and Alexandra Brown in 1985, the Chameleon Club was originally located in the back room of a prominent fine dining restaurant called Tom Paine's in honor of Thomas Paine.

At its conception, the small approximately 100 person capacity room offered performances of live, original music in Lancaster.

[1] In 2008, a major renovation took place in which the adjacent building was acquired and integrated into the existing facility.

[4] Although the article stated that a new venue would open in 2021, as of June they are only promoting events in other locations on their Facebook page.