It is the short-lived spin-off of Lamb Chop's Play-Along and was hosted by Shari Lewis, whose strong belief in the benefits of music education for children led to the creation of the series.

The Charlie Horse Music Pizza was shot at the CBC Studios in Vancouver, British Columbia, Canada.

Alongside the original cast of Lamb Chop, Hush Puppy, Charlie Horse, and Lewis, Charlie Horse Music Pizza introduced five new characters: Take Out, a big anthropomorphized dim-witted orangutan who makes deliveries on roller skates (played by Chancz Perry); Fingers, a giant, sassy purple raccoon that lives in the dumpster behind the pizzeria (played by Gordon Robertson); Cookie, the soft-hearted opera loving cook (played by Dom DeLuise), Junior, a cool teenager who works at the pizzeria part time and plays the tuba for his high school marching band (played by Wezley Morris), and Holly, a young girl in a wheelchair (played by Chantal Strand).

[2] After Shari was diagnosed with inoperable uterine cancer, the show was put on hold on June 18, 1998, while she underwent chemotherapy at Cedars-Sinai Hospital.

[4] The last episode of The Charlie Horse Music Pizza aired on January 17, 1999, on what would have been her 66th birthday.