The sixth season of Desperate Housewives, a television series created by Marc Cherry, began airing on September 27, 2009, and concluded on May 16, 2010.

The deceased Mary Alice Young continues to narrate the events in the lives of her friends and Wisteria Lane residents, Susan Delfino, Lynette Scavo, Bree Hodge, Gabrielle Solis and Katherine Mayfair.

The sixth season also started airing at 10:00 pm on Channel 4 in the United Kingdom on January 27, 2010, as well as on the Seven Network in Australia on February 1, 2010.

After including DVR playback (Live+7 days), the season average number increased to a 5.0 rating, placing eighth, in terms of scripted shows.

Marc Cherry revealed that the sixth season mystery will pay homage to a classic Dallas storyline.

The series is narrated by Brenda Strong, who portrays the deceased Mary Alice Young, as she observes from beyond the grave the lives of the Wisteria Lane residents and her former best friends.

Dana Delaney portrayed Katherine Mayfair, who endures a mental breakdown after Mike leaves her to remarry Susan.

New additions to the main cast included Drea de Matteo playing Angie Bolen, whose mysterious arc is the season's main storyline,[11] and Maiara Walsh in the role of Ana Solis, Carlos's rebellious niece who moved to Wisteria Lane in the fifth season finale.

[12] Shawn Pyfrom did not return as a regular; he instead made guest appearances as Andrew Van de Kamp, Bree's gay son.

Additionally, child actors Madison De La Garza (Juanita Solis) and Mason Vale Cotton (M.J. Delfino) were promoted from co-stars to also starring.

Tuc Watkins and Kevin Rahm respectively played Bob Hunter and Lee McDermott, a gay couple and residents of Wisteria Lane.

Part of the main mystery arc were John Barrowman appearing as Patrick Logan, an eco-terrorist and Danny's biological father, Julie McNiven playing Emily Portsmith, a barrista at a local cafe and acquaintance of Nick, and Ellen Crawford portraying Iris Beckley, a neighbor of Angie's mother that informs Patrick of the Bolens' whereabouts.

Maria Cominis played Mona Clarke, a Wisteria Lane resident who blackmails Angie when she discovers her secret.