Artists such as Nirvana, Pearl Jam, Alice in Chains, Soundgarden, Mad Season, R.E.M., Ann Wilson, Mudhoney, Cheap Trick, Yoko Ono, Social Distortion, Green Day, The Strokes, Beastie Boys, Porcupine Tree, Alice Merton, Billie Eilish[5] and Tom Morello[6] have performed at the club.

[9] During its initial 16-year run, the Croc hosted numerous well-known acts including Mudhoney,[9] Tad,[9] Nirvana,[9] Palomar, Pearl Jam,[9] Sunny Day Real Estate,[9] Everclear,[9] Mad Season,[9] Green Day,[9] The Strokes,[9] Joanna Newsom,[10] Cheap Trick,[9] Indigo Girls,[11] Robyn Hitchcock,[9] Porcupine Tree,[12] Glenn Tilbrook,[13] Rhonda Vincent,[14] Death Cab for Cutie,[9] Yoko Ono,[9] Ann Wilson,[11] Sleater-Kinney,[9] R.E.M.,[9] Soft Boys, Built to Spill,[9] Neutral Milk Hotel,[15] Dinosaur Jr.,[11] Beastie Boys,[9] Corinne Bailey Rae,[11] Rachael Yamagata, Kevn Kinney of Drivin N Cryin, Ventures,[11] Chris Knox, The Presidents of the United States of America,[9] and Harvey Danger, who chose the Cafe for their final performance.

[17] In February 1996, Seattle's Popllama Records released the compilation album Bite Back: Live at the Crocodile Cafe, which featured bands such as The Walkabouts, Girl Trouble, Flop, and Gas Huffer.

[3] The closing of the Crocodile Cafe, a fixture of the local music scene, caused widespread speculation in regard to the future of the establishment.

The Man guitarist Eric Howk, and Capitol Hill Block Party co-founder Marcus Charles purchased the establishment.

[23] On October 9, 2013, R&B singer JoJo performed "Smells Like Teen Spirit" during the final stop of her West Coast promotional tour.

[26] On August 23 and 24, 2018, The Crocodile hosted a pop-up shop and retrospective for Alice in Chains featuring rare photos, limited-edition merchandise, memorabilia and music gear that showcased the band's 30+ year career.

[27] In November 2020, the owners announced that the venue would be moving from its original Belltown location a few blocks away to the former site of the Sailors’ Union of the Pacific lodge at 1st Avenue and Wall Street.