The Demi Lovato Show features candid conversations with special guests and covers topics including activism, feminism, gender identity, sex and body positivity, mental health and UFOs.

[2] Executive producers were expected to include Lovato, Scooter Braun, J. D. Roth, Allison Kaye, Scott Manson, and Adam Greener with Hannah Lux Davis was slated to direct.

Production companies involved with the series were slated to consist of GoodStory Entertainment and Braun's SB Projects.

[4] In January 2021, Roku, Inc. acquired Quibi's programming and announced plans to release the series during that year.

[6] It was revealed that guests would include Lucy Hale, Jameela Jamil, YG, and Nikita Dragun.