He has been assigned to kill a fence and cocaine dealer named Hubbard by the Royal Academy (which is a front for the British Secret Service in the Box novels).
While on board, Box discovers the ship is transporting cocaine disguised as communion wafers and seduces the cabin-girl Aggie, whose real name turns out to be Agnes Dei ("Lamb of God").
He witnesses the spectre of the ram's head again and meets Mrs Croup who has an intense and unhealthy interest in famous murderers.
There Box discovers that Olympus Mons and his amber shirted thugs have arrived first and witnesses them murder several nuns while seeking Aggie.
Box is forced to kill Flarge's domestic "Twice" Daley in an escape attempt but ends up being chloroformed by Professor Reiss-Mueller.
On awaking Delilah relates how the Professor intended to perform the ritual himself and reap the reward, but was killed by a goat headed spectre.
The party of three enter caves below the castle and discover Mons, Pandora and the FAUST fraternity preparing to sacrifice Aggie.
The Satanists are met by a number of cloaked and robed VIP's including Joshua Reynolds, the head of the Royal Academy and the boss of Box and Flarge.
When the ritual begins Box intervenes and succeeds in rescuing Aggie and banishing the Devil but only at the cost of the life of his sister, Pandora.
Mons attempts to undo the damage Box has done but only succeeds in destroying himself and bringing down the roof of the cave system.
In addition to being a portrait painter, wit, dandy and indiscriminate rake, Lucifer Box is an agent of the British Secret Service, reporting to Sir Joshua Reynolds.
The previous holder of the position was featured in The Vesuvius Club but died of heart trouble before the time at which The Devil in Amber is set.
Since then he served in the British Army, specifically during action on the border of France and Switzerland which caused him to suffer a mental breakdown.
Entered the service of Lucifer during the events in The Vesuvius Club after Box's previous servant, Poplar, was shot in the back on a Serbian railway station.
Died in military action before the beginning of The Devil in Amber during an undisclosed adventure that took place on the French/Swiss border during World War I.