Determined to learn what Phil Coulson has been planning, Melinda May orders Jemma Simmons to open the toolbox, forcing her to admit it is a fake.

Jiaying has Gordon bring Cal back to his former office in Milwaukee, under the pretense that he is on a simple excursion to collect his belongings, but the Inhumans intend to abandon him there.

In March 2015, Marvel announced that the eighteenth episode of the season would be titled "The Frenemy of My Enemy", to be written by Monica Owusu-Breen and Paul Zbyszewski, with Karen Gaviola directing.

[1] Executive producer Jeffrey Bell explained "The Frenemy of My Enemy"'s place in the overarching story of the season, saying that it "really sets up nicely the final four, which I think kind of move like a train.

"[2] In March 2015, Marvel revealed that main cast members Clark Gregg, Ming-Na Wen, Brett Dalton, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Nick Blood, and Adrianne Palicki would star as Phil Coulson, Melinda May, Grant Ward, Skye, Leo Fitz, Jemma Simmons, Lance Hunter, and Bobbi Morse, respectively.

List, Kyle MacLachlan as Cal, Jamie Harris as Gordon, Maya Stojan as Kara Palamas, Dichen Lachman as Jiaying, Luke Mitchell as Lincoln Campbell, Kris Lemche as Ethan, Staci Roberts as Paula, and Trenton Rostedt as Hoodie Guy.

[3] Simmons, Goodman, MacLachlan, Harris, Stojan, Lachman, Mitchell, Lemche, Kassianides, and Richards reprise their roles from earlier in the series.

The different artists were once again chosen to create the teaser posters, based on their previous work and how it connected to the themes and emotion of the intended episode.

[9] Marvel teamed with Nathan Fox on the poster for "The Frenemy of My Enemy", which depicts Ward, Kara, and Bakshi in "Hydra red"; Coulson, Hunter, and Fitz in "S.H.I.E.L.D.