Recent acquisitions include artwork by James Surls, Andy Warhol, Melissa Miller, David Bates, Helen Altman, Russell Lee, Bob Stuth-Wade, Beili Liu, Vernon Fisher and others.

Recent exhibitions include Texas Modernists; Home on the Range: Where the Prairie Meets the Plains in Central West Texas; Beili Liu: Stratus; Julie Speed: Paper Cut; Drawn In / Drawn Out: Contemporary Drawing and Melissa Miller: Habitat.

The history galleries on the third-floor feature permanent exhibits of recreations of 1906, 1926, and 1946 Abilene parlors and kitchens, a 1920 Grace Hotel guestroom, and a historic bootmakers shop.

The gallery features a replica of Abilene's Paramount Theatre, an interactive sound wall, Texas tornado, life-size Operation game, children's art exhibits, a dinner, and a historic Dixie Pig Restaurant sign.

The Prairie Style Hotel Grace was initially a three-story structure, a fourth story was added in 1924.

The Drake Hotel eventually ceased operation in 1973 after passenger railroad traffic and subsequently downtown Abilene declined thought the 1960s.