The Grande at Santa Fe Place is a high-rise residential building in San Diego, California, United States, composed of two towers of equal height.

The 39-story towers have a height of 420 feet (130 m) and are a prominent fixture in San Diego's skyline.

The towers are currently tied with Vantage Pointe Condominium as the tenth-tallest buildings in San Diego.

The two towers were constructed by Downtown San Diego's largest developer of residential property, BOSA Development Corp., and were designed by Perkins & Company Architecture and Urban Design Inc. Construction for the South Tower began on April 25, 2002 and was completed in 2004.

Each tower features 221 residential units, and is based on late-modernist architectural style.