Cheung Yat Kin (Kenneth Ma) and Fan Chi Yu (Tavia Yeung) are now happily married to each other but life ahead is not easy for them.

Chi Yu finds herself pregnant but her intramedullary spinal cord tumour relapsed to which makes her unfit to continue with the pregnancy.

His mother also falls sick which added pressure on him, causing him to develop an anxiety disorder and stomach ulcer from chronic indomethacin (Motrin) use.

[1] The challenges that he has to face with Chi Yu on top of his stubborn personality takes a toll on his relationship with newly transferred pathology specialist, Lok Man Sang (Lawrence Ng).

Lokman gets involved with fellow internal medicine doctor, Heung Chin Yi (Tracy Chu), who happens to be twenty years younger than him.

Lokman is a widowed man with a young daughter Yannis (Elkie Chong) while Chin Yi is left having to take care of her runaway (later revealed as deceased) boyfriend's son.

Meanwhile, Chi Yu’s sister, neurosurgeon Hong Mei Suet (Mandy Wong) also has her own challenges to face as she finally becomes a doctor in her own right.

As his career picks up, he finds himself in a love triangle with his crush in Australia Ching Ching (Candy Chang, who appears in cameo), training doctor Chung Tsz Ting (Crystal Li) and Che Hiu Tung (Eliza Sam), 26 year old a social worker volunteer, who suffers from a chronic illness, brainstem glioma, partially resected at age 16 with a life expectancy of 3 to 10 years.