Paisley Wu's formative years were spent in Shanghai, where she received musical training in Italian opera.
In 1996, she signed with Musician Ltd, a short-lived sublabel of Polygram Hong Kong which was then home to the newly reformed Tat Ming Pair, and during this period released music that showed a more alternative-rock influence.
In late 2007, she made a brief return to the Hong Kong music scene with the EP Don't Think Just Do, which featured her first ever number one single, "Letting Go."
Throughout her career, Wu has collaborated and recorded with Tats Lau, Jan Lamb, and Anthony Wong Yiu Ming in the mid-90s, as well as Lazy Mutha Fucka and Edison Chen in 2004.
In 2008, Wu married Pal Sinn, a former member of 80s Hong Kong rock band Blue Jeans and a frequent songwriter on her albums.