The Incredulity of Saint Thomas is a 1543–1547 painting by Francesco Salviati.

[1] It was commissioned for the église Notre-Dame-de-Confort in Lyon by Thomas II de Gadagne (also known as Tomaso Guadagni), a Florentine counselor to Francis I of France.

[3] Its choice of subject reflects an anti-Medici political viewpoint shared by commissioner and artist.

[4][5] The work proved popular from its arrival in Lyon onwards and was copied by several artists in several media, including an engraving by Master CC.

[6] Even after art history began to neglect art produced in and for Lyon, the painting was one of few such works still to be mentioned - for example, it appears in Giorgio Vasari's Lives.