He inherited a large fortune from his uncle Thomas I de Gadagne as well as solid commercial and financial positions.
He increased this fortune, allowing him to lend to major French nobleman and even Francis I of France himself, who made him a counselor and 'maître d'hôtel ordinaire' in his household.
[1] In 1537 he founded the Basilique funéraire Saint-Laurent de Choulans [fr] hospital, with its pavillon Saint-Thomas for plague sufferers.
[1] He commissioned The Incredulity of Saint Thomas for his uncle's burial chapel.
Thomas II let out the hôtel de Gadagne to the Pierrevive family from 1538.