The program had its "Preview" while Behar filled in as a week-long host on Viewpoint with Eliot Spitzer on June 18, 2012, and officially premiered on Current TV on September 4, 2012.

The final episode of the Current TV program aired on August 1, 2013, as the network prepared to transition to Al Jazeera America.

Some guests who appeared on the HLN show include: Kate Gosselin, Jeff Ross, Joan Rivers, Kathy Griffin, Bette Midler, Christopher Hitchens, Ann Coulter, Michael Moore, Jeanine Pirro, Sarah Silverman, Bill Murray, Jane Curtin, Gilbert Gottfried, Betty White, Roseanne Barr, Dolly Parton, Linda Evangelista, The Go-Go's, Wendie Malick, Rita Moreno, Victor Garber, Gloria Estefan, Rosie O'Donnell, Steve Martin, Perez Hilton, Linda Gray, Susie Essman, Carrie Fisher, Arianna Huffington, Martin Short and Valerie Bertinelli.

[3] On July 31, 2012, Current TV announced that the program would debut on September 4, 2012 and would be titled Joy Behar: Say Anything!.

premiered on Current TV on Tuesday September 4, 2012 at 6:00e/3:00p with guests Darrell Hammond, Al Gore, Judy Gold and Rob Shuter.