[2] The series focused on four preteen "sleuths"[3][4] who solve mysteries in their fictional small town of Ambrosia, Arizona.

12-year-old Mike Fowler lives in the fictional small town of Ambrosia, Arizona with his apparently widowed mother and his paternal grandparents.

The family runs the Last Chance Gas and Diner highway stop near the town's municipal limits, as well as the small hangar and airstrip nearby.

The diner property is also home to Lady Liberty, a B-17 Bomber[5] flown by Mike's grandfather in World War II; it is in the plane that Mike and his three friends—Ben Jones, Winnona "Winnie" Whitefeather, and Spencer Williams – run their detective agency called the "Last Chance Detectives".

The radio series included a brand new cast, and Jason Whittaker, from Adventures in Odyssey in the first album.