A ten-episode second season, or "Book 2", titled The Last Kids on Earth and the Zombie Parade, premiered on April 17, 2020.

[2] On September 26, 2017, it was announced that Thunderbird Entertainment's animation studio Atomic Cartoons had optioned the screen rights on Max Brallier's book series The Last Kids on Earth with the intention of producing an animated television series.

Executive producers include Brallier, Scott Peterson, Jennifer McCarron, and Matthew Berkowitz.

Production companies involved in the series include Thunderbird Entertainment's animation studio Atomic Cartoons.

[8][9] On March 13, 2019, the series cast was announced, including Mark Hamill, Rosario Dawson, Catherine O'Hara, Keith David, Bruce Campbell, Garland Whitt, Montserrat Hernandez, Charles Demers, and Nick Wolfhard as the lead character Jack Sullivan.