[2][better source needed] The show primarily focused on politics, pop culture, and media bias; topics of interest included race relations, trends in education, the Middle East, and the legacy of feminism.

[3] Ingraham's show, one of several to launch in 2001 as the conservative talk radio genre expanded in popularity, originally aired on the now defunct Westwood One Network.

[11][12][13] Ingraham discussed current events and media reports about the War on Terror and what she believes to be a growing faction of Islam: Jihadists.

[14][15] Ingraham often discussed bioethical issues, opposing legal elective abortion care,[16] human cloning and embryonic stem-cell research.

She was an outspoken opponent of Missouri Constitutional Amendment 2 (2006), a ballot measure legalized human cloning; Ingraham argued that the initiative was deceptive.