Brain and his lab rat Rathbone, and puzzles need to be solved to put Dr.

Previous installments featured a large, semi-free-roaming environment, but The Lost Mind of Dr.

Brain's niece, Elaina (voiced by Kayce Glasse) replaces Dr.

The game scored positive reviews by Computer Shopper as entertaining in August 1995 and by PC Gamer for having "educational value" in December 1996.

[5] Next Generation gave three stars out of five for Macintosh version of the game, and commented that its gameplay and simplicity is appropriate for younger audience.