[2] As onlookers begin to gather though, the two androids become nervous about attracting attention and abruptly take off with Jerry and Alice.

The series follows the foursome as the two androids (who bicker and argue incessantly with each other, neither seeming competent with the ship's controls) encounter various adventures while trying to get Jerry and Alice back home or return to their own home on planet ZR-3 where they hoped to make repairs with the help of their lookalike creators Doctor Locker (Nabors) and Professor Pringle (Buzzi dressed as her purse-wielding spinster character Gladys from Rowan & Martin's Laugh-In).

Typically, episodes were blatant social commentaries dealing with extremes such as a world where names (and faces) were replaced with numbers, where machines were outlawed due to a global energy shortage, or a city where the population had grown lazy and obese because robots do all the physical work.

Accompanying them on their adventures was a creature known as the Dorse (played by Larry Larsen) which was a half-dog, half-horse hybrid with the body of a large shaggy dog and the head of a small horse.

"Fat Is Beautiful", for example, depicted a future in which people were grotesquely obese due to over-dependence on push-button conveniences, and leanness was in fact outlawed.