The franchise primarily focuses on Lincoln Loud, the only boy and the middle child in a family of eleven children (with ten sisters of distinctive personalities) residing in the fictional town of Royal Woods, Michigan, who occasionally breaks the fourth wall to explain to the viewers the chaotic conditions and sibling relationships of the household, and continually devises plans to make his life in the Loud House better.

Since its debut, the franchise has gained high ratings, with the original series becoming the top-rated children's animated series on American television within its first month on the air,[1] further receiving considerable media attention and nominations at both the 28th and the 29th GLAAD Media Awards for its inclusion of Howard and Harold McBride, two supporting characters who are an interracial gay married couple.

[4] Early in development, the Loud family was going to be composed of rabbits, but this was terminated when an executive, Jenna Boyd, asked Savino to make them human.

A mobile game based on the series called The Loud House: Ultimate Treehouse was released on September 20, 2018, for iOS and Android.

[49] Lincoln and Lucy are also playable in the 2021 title Nickelodeon All-Star Brawl;[50] a patch to the game added voice acting with their roles being reprised by Bentley Griffin and Jessica DiCicco.