Nick Cannon, singer-songwriter Robin Thicke, television and radio personality Jenny McCarthy Wahlberg, actor and comedian Ken Jeong, and recording artist Nicole Scherzinger all returned for their fourth season as host and panelists.

After each masked singer performed for the first time along with an initial clue package, each panelist wrote their first impressions-based guess at the identity of the celebrity and kept in a safe until the men in black are instructed to bring it out upon a contestant's elimination.

[8] Due to the COVID-19 pandemic in the United States, various industry-adopted safety protocols were implemented for production (as well as a change in location from Television City to Red Studios Hollywood), which included that the tapings to have a virtual audience, and that the judging panel would be 8 feet apart from each other.

Fox Alternative Entertainment president Rob Wade said that the show would still "feel very much like" past seasons, having employed "various quarantining and various camera tricks" to preserve the visible presence of a studio audience.

[9] Executive producer Craig Plestis stated that a goal for season four's costumes was to "increase the bonkers level and keep the production values up".