The Mightiest Machine is a science fiction novel by American writer John W. Campbell, Jr.

It also touches on the legends of ancient civilizations on earth, Mu in this case, and what may have happened to them.

Astounding reviewer P. Schuyler Miller described the 1947 edition as "perhaps the climax of the super-physics school of science fiction which 'Skylark' Smith had started.

"[1] Everett F. Bleiler identified the novel as the paradigm of "the Campbell hard space opera," noting its "great quantity of fanciful and ingenious scientific extrapolations, fictional weaknesses, and polarized social simplistics that regard genocide with equanimity.

The protagonist also invents and employs devices such as Infrared vision googles and miniature remotely piloted surveillance drones.