The episode deals with Cardinal della Rovere's having fled to the Kingdom of Naples in fear for his life, and in search of support for his plot to depose the Pope.
Cardinal Giuliano della Rovere (Colm Feore) arrives in Naples and is given an audience with King Ferrante (Joseph M. Kelly) and Prince Alfonso (Augustus Prew).
When the Pope (Jeremy Irons) learns of his arrival in Naples, he asks his son Cesare (François Arnaud) if he knows of someone who could kill the Cardinal.
While emptying della Rovere's estate, Cesare meets with Micheletto (Sean Harris) and tells him to travel to Naples to assassinate the Cardinal.
Reforming his plan, he attempts to kill della Rovere at a sulphur bath, but is discovered by the Cardinal, recognizing Micheletto's badly scarred back.
The Pope consults Giulia Farnese (Lotte Verbeek) and Cesare on a request from the Sultan of Constantinople to house his half brother, Prince Cem (Elyes Gabel), for 40,000 ducats a year.
While watching Cem and Juan practice swordplay, the Pope reveals to Cesare that the Sultan offered him 400,000 ducats if Djem were to die while in their care.