It was written and directed by series creator Neil Jordan and originally aired on April 3, 2011, as the first half of a 2 hour premiere.
Pope Innocent VIII (Michael Poole) calls the College of Cardinals into his bedchamber to hear his final words.
Bishop Cesare Borgia (François Arnaud) arrives at the Vatican just before it closes for Papal conclave, where Rodrigo tells him of his intention to be elected Pope.
Immediately following his election, he is accused of simony by Cardinals della Rovere and Orsini, but they are made silent after Rodrigo reminds them that he must select a Vice Chancellor, which includes a higher income.
Later at his home, his mistress and the mother of his children Vannozza dei Cattanei (Joanne Whalley) is displeased when he denies her affections, as he must appear to be celibate.
After a short fight, Cesare hires the servant, who reveals himself as an assassin named Michelotto (Sean Harris), to serve Cardinal Orsini poisoned wine.