Cameo appearances by Delbert the La Choy Dragon (on a shield), a Skeksis from The Dark Crystal, Lew Zealand, Zoot, Floyd Pepper, Dr. Teeth, Slim Wilson, Statler and Waldorf, Pigs, Penguins, Rizzo the Rat, Seymour the Elephant, Foo-Foo, Sweetums, Link Hogthrob, Dr. Julius Strangepork, Clueless Morgan, Catgut the Cat from The Muppet Musicians of Bremen, Leroy the Donkey from The Muppet Musicians of Bremen, T.R.

Plot, Angus McGonagle, Lips, Quongo the Gorilla, Thog, Kangaroo, Marvin Suggs, Louis Kazagger, Crazy Harry, Uncle Deadly, Bobby Benson, Koozebanian Phoob, Mean Mama, Lou, Gladys, Jim, Pops, Whatnots, Frackles, Cows, and Horses.

Cameo appearances by Foo-Foo, Beauregard, Sam Eagle, Uncle Deadly, Crazy Harry, Dead Tom from Muppet Treasure Island, Headless Bill from Muppet Treasure Island, Marvin Suggs, Angus McGonagle, Bobby Benson, Johnny Fiama, Wayne and Wanda, Mahna Mahna, The Snowths, Sal Minella, Bad Polly, Clueless Morgan, Mad Monty, Annie Sue, Bunsen Honeydew, Beaker, Thog, Doglion, Timmy Monster, The Mutations, Behemoth, Beautiful Day Monster, Blue Frackle, Green Frackle, Big V, Gorgon Heap, Luncheon Counter Monster, and the Dragon from Sleeping Beauty.

An adaption of Sherlock Holmes with Gonzo as the title character, Fozzie Bear as Dr. Watson, Kermit the Frog as Inspector Lestrade, and Miss Piggy in various female leads.

Dan Crown of IGN gave the first issue an 8.2 out of ten, saying "The idea of using a sketch comedy show as a vehicle for various and unique comic strips is borderline inspired.