It is located along Argwings Kodhek Road, Upper Hill, Nairobi.

The hospital is located approximately 3 kilometres (2 mi) west of Kenyatta International Conference Centre.

[4] The institution was officially opened on 9 April 1954, as an exclusively European Hospital, in Kenya, which was then a colony of the United Kingdom.

On 19 October 1961, it began serving non-Europeans and the name was changed to The Nairobi Hospital.

The hospital's total assets were valued at approximately KES:12 billion (US$94 million, at that time).