In addition to an extensive trade book selection, The Odyssey is the exclusive provider of textbooks for Mount Holyoke College[1] and hosts author readings and book club events.

In 1957, he bought and managed Glesmann's Pharmacy, which was located across the street from Mount Holyoke College.

The pharmacy, however, began to reflect Grenier's interest in literature as it became a gathering place for author readings and book club events.

[1] During the 1980s, The Odyssey was damaged by two fires but in 1991, the ownership of the business passed to Romeo's daughter, Joan Grenier, who oversaw the re-location of the shop to its present location as the anchor store of the Village Commons.

[1] In 2017, The Odyssey replaced the college's campus store as the official supplier of Mount Holyoke-branded spirit apparel and other items.