The first season of Prison Break, an American serial drama television series, commenced airing in the United States and Canada on August 29, 2005, on Mondays at 9:00 p.m. (EST) on Fox.

Prison Break is produced by Adelstein-Parouse Productions, in association with Rat Entertainment, Original Film and 20th Century Fox Television.

The executive producers were creator Paul Scheuring, Marty Adelstein, Neal H. Moritz, Dawn Parouse, Brett Ratner and Matt Olmstead.

[23] The season has a 77% rating on Rotten Tomatoes, with the site's consensus stating: "Prison Break is confident pulp with a crackerjack premise that spreads thinly enough to smooth over the show's more lunkheaded flourishes.

[27] Based on its strong opening, The New York Times dubbed Prison Break "more intriguing than most of the new network series, and ... one of the most original" and a "suspenseful thriller", complementing its "authentic look".

[32] Prison Break was originally planned for a 13-episode run, but was extended to include an extra nine episodes due to its popularity.