[10] The show began with a cold open sketch called "Ex-Men" (a parody of X-Men) in which Pete played Professor X firing Wolverine for being useless.
On May 23, 2014, TBS announced the cancellation of The Pete Holmes Show, citing insufficient audience numbers.
After the first commercial break, a remote segment or another sketch was shown, or a live comedy bit was performed.
Most notably, the final episode entirely lacked a monologue, and was closed with the show's only musical performance ("Poke" by Scott Hutchison of Frightened Rabbit).
[13] The show was taped in front of a live studio audience on Stage 10 of the Warner Bros. lot in Burbank, California.
Conan O'Brien, Jeff Ross, Nick Bernstein, and Dave Rath are presumed to have been involved in production.