The Principles and Practice of Medicine

It was first published in 1892 by D. Appleton & Company, while Osler was professor of Medicine at Johns Hopkins University.

The book established Osler as the world's leading authority in the teaching of modern medicine.

[1] The text was translated into French, German, Russian, Portuguese, Spanish and Chinese, and for over 40 years it was the world's most significant medical textbook.

[2] Osler dedicated the book to his teachers; William Arthur Johnson, James Bovell and Robert Palmer Howard.

There are 11 sections, preceded by a list of charts and illustrations.