After accidentally causing the death of his son, geneticist William Blakely wakes in a house tended by a man who introduces himself as his twin brother.

William can remember nothing of his life and must be taught basic concepts, such as how to walk and respond to knock-knock jokes.

Before William 1 can do anything further, his boss, Dr. Archer, takes him to see several security agents, who accuse him of stealing the lab materials.

He awkwardly reestablishes contact with her, though she initially rejects him, as she feels abandoned and left alone to deal with her grief.

Meanwhile, William 1 escapes his bonds and kills a Next Corp security agent who was investigating the house and its grounds.

William 2 reluctantly agrees, and goes to work at Next Corp, where he learns that the animal test subjects are second generation clones.

[5] John DeFore of The Hollywood Reporter described it as a "thoughtful, intimate film [that] works both as sci-fi and family drama".

[6] Robert Abele of the Los Angeles Times wrote, "The Reconstruction of William Zero has its own identity problem, essentially, being a solid sci-fi story with a welcome emotional component, yet never fully effective at either.

"[7] Kurt Halfyard of Twitch Film compared it to Another Earth and called it "more vexing than cathartic".

[8] Matt Boiselle of Dread Central rated it 2/5 stars and called it "sad and complex" but "hard to swallow and possibly even harder to digest.

Club rated it C− and wrote, "It's always easy to see what Bush and Byrne are aiming for with this timely piece of speculative fiction.