The titular phrase, which refers to declining interest in a monogamous relationship after seven years of marriage, has been used by psychologists.

[1] The play was filmed in 1955 as The Seven Year Itch, directed and co-written by Billy Wilder and starring Marilyn Monroe and Ewell, reprising his Broadway role.

The stage version premiered at the Fulton Theatre on November 20, 1952, and closed there on August 13, 1955, after a run of 1,141 performances, making it the longest-running non-musical play of the 1950s.

[4] The touring production starred Eddie Bracken as Richard Sherman and also featured Gena Rowlands as Elaine.

[6] An American husband, married for seven years, fantasises about his adventurous past, and future, particularly with "the girl" who moves into his apartment block.