Their owners are unseen stock characters only viewed from the neck down and named (appropriately enough) Husband & Wife (voiced by Steve Mackall and Tress MacNeille).

Pith Possum fights various enemies with his recurring one being a mad lumberjack named Dr. Paul Bunion (voiced by Jim Cummings).

It was stated in the first episode that Pith Possum was an ordinary lab opossum until he gained ultra opossum-like abilities upon an experiment gone wrong.

Dr. Paul Bunion creates a group of wooden robots in order to pull off a large string of robberies.

They eat rotten cocktail weenies to survive, until they start hallucinating that a gang of living food is chasing them.

Ralph Bear and Al Dog pose as Pith Possum and Obediah where they go on a crime spree to frame them.

Shnookums is alarmed when his owners buy a dog named Meat, but he learns kung-fu to defend himself.

Super Water Buffalo organizes his own crimes to stop in order to outdo Pith Possum.

The pet fish learns how to make itself evolve, and turns into a giant monster that terrorizes Shnookums and Meat.

Dr. Paul Bunion enlarges a lizard to gigantic size so that he can have it uproot the trees in Possum City.

Pith Possum gets his brain damaged by his Cranium Crasher Mariachi Cannon and starts acting like different people.

Shnookums works to cut up Mr. Gobble for Thanksgiving dinner, but Meat is determined to save his new friend.

These episodes were: The series aired on The Disney Afternoon on Mondays between January 2 and March 27, 1995, in the timeslot normally occupied by Bonkers.

The Tex Tinstar segments were shown out of order on Disney Channel UK in 2003 to fill the then frequently gapped schedule.

Following the launch of the Disney+ video on demand streaming service in November 2019, Shnookums and Meat along with Aladdin (based on the 1992 film of the same name) are the only Disney Afternoon series not seen yet on the platform.

[8] Evan Levine of the Newspaper Enterprise Association noted that his son liked it, and felt that it had good animation and clever humor, saying that "kids may enjoy the freewheeling mix of physical comedy and silliness".