They induce his Terrigenesis, giving him the ability to explosively charge objects (in a similar manner to an Extremis combustion), and Hive enthralls him, learning he buried the companion artifact beneath his home.
Meanwhile, Fitz, Simmons and Alphonso "Mack" Mackenzie decide to seek out Holden Radcliffe, who was in charge of Transia's work against invasive organisms, before he was fired for his transhumanist beliefs.
While continuing to discuss how to proceed with their relationship, Fitz and Simmons infiltrate a transhumanist social club to find Radcliffe, under the guise of geneticists wanting to sell him eye prosthetic technology based on those used for Project Deathlok.
Under Coulson's direction, Glenn Talbot and the Advanced Threat Containment Unit (ATCU) use information Gideon Malick provided before his death to neutralize what is left of Hydra, with the exception of the forces commanded by Hive.
In an end tag, Hive brings Daisy, Radcliffe, Alisha, and James (who has chosen the moniker "Hellfire") to a town he bought with Malick's money.
[1] In April 2016, Marvel revealed that main cast members Clark Gregg, Ming-Na Wen, Brett Dalton, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, Nick Blood, Adrianne Palicki, Henry Simmons, and Luke Mitchell would star as Phil Coulson, Melinda May, Hive, Daisy Johnson, Leo Fitz, Jemma Simmons, Lance Hunter, Bobbi Morse, Alphonso "Mack" Mackenzie, and Lincoln Campbell, respectively.
[1] It was also revealed that the guest cast for the episode would include Axle Whitehead as James, John Hannah as Holden Radcliffe, Alicia Vela-Bailey as Alisha, Adrian Pasdar as Brigadier General Glenn Talbot, Alexander Wraith as Agent Anderson, Camille De Pazzis as Anon and Rudy Dobrev as bartender.
For the episode's opening long take shot, the cameraman wore a wire rig usually reserved for actors and stunt doubles so he could be maneuvered around and above the set.