The South-Carolina and American General Gazette was an 18th-century newspaper published in colonial Charleston, South Carolina.

Aside from some periods of suspension during the American Revolutionary War, it published until February 1781.

When Charleston and the paper fell under British control, it published under the title The Royal Gazette from March 1781 and into 1782.

[8] When Wells' son John took over the paper in 1775, he moved its political stance to the cause of independence, but primarily as a business decision.

In January 1781, his brother William C. Wells came to town to assist, and to report that under British control, the paper now had received the royal printing business.