Prior to working on The Spider Labyrinth, director Gianfrano Giagni in radio and television since the mid-1970s.

[2] Producer Tonino Cervi liked Giagni's short and offered him a job to direct his first feature, the horror film The Spider Labyrinth.

[2] The original script for the film was developed by Cervi, Riccardo Aragno and Cesare Frugoni which dated a few years before production started.

[2] Giagni felt the script was a bit dated, and got Gianfranco Manfredi in with him to give the film a more modern framing.

comparing scenes to the work of Dario Argento and Mario Bava.