It was designed by architect Charles E. Cassell (1838–1916), who was a founding member of the AIA Baltimore chapter, and also designed the Christian Science Temple, Chamber of Commerce building, and Stewart's Department Store in Baltimore.

The building itself is clad in brown Roman brick, and features arched windows and balustrade balconies – all of which is done in the Richardsonian/Romanesque architectural style.

The building is located on the north face of Mount Vernon Place, a cross-shaped park composed of 4 landscaped squares, featuring the Washington Monument at its center.

Today, The Stafford is a 96-unit apartment building; housing primarily students from the nearby Johns Hopkins University's Peabody Institute.

Community amenities include a fitness center, laundry facility, and common room.