Grimes played Tammy Ward, a spendthrift heiress under the financial thumb of her Uncle Simon (Hiram Sherman).

The series also stars Dick Sargent (billed as Richard) as Tammy's uptight twin brother Terrance, with whom she works at their Uncle Simon's bank.

In an unusual move for a major television network at the time, ABC opted to cancel the series after just four episodes.

"[5] The Tammy Grimes Show was created by George Axelrod and executive produced by William Dozier.

The original pilot episode, written by Axelrod (in which Tammy posed as a "Texas millionaire" to apply for the bank's credit card, sparking a spending spree), was never shown; scenes from it were presented during ABC's "fall preview" presentation at their annual affiliate meeting in the summer of 1966.