The Twelfth Card is a crime novel by American writer Jeffery Deaver, the sixth in the series featureing Lincoln Rhyme.

The story starts out in a museum where Geneva Settle, a high-school student in Harlem, is researching information for a paper about her ancestor, Charles Singleton.

Amelia Sachs, Fred Dellray, Mel Cooper, and Lon Sellitto help Lincoln to solve why Boyd is after Settle.

Rhyme had discovered through the investigation of the crime that Geneva's ancestor was falsely accused of murder and had his land stolen.

[2] Gilbert Cruz, from Entertainment Weekly, related the CBS hit, CSI, to the novel in his review by saying that the procedures used to dissect a crime scene are the same, even though it is denied in the book.