[1] The Weekenders details the weekends of four best friends: Tino Tonitini (voiced by Jason Marsden), a friendly and ambitious Italian-American boy; Lorraine "Lor" MacQuarrie (voiced by Grey DeLisle), a hyperactive and dull-witted Scottish-American girl; Carver René Descartes (voiced by Phil LaMarr), a vain and materialistic African-American boy who is of Haitian descent; and Petratishkovna "Tish" Katsufrakis (voiced by Kath Soucie), a highly intelligent and bibliophilic Jewish-American girl of Eastern European descent (the fictional country where she was born is identified throughout the series simply as "the Old Country").

The implied "ticking clock" is used to signify the characters running out of time and the problem must be solved before going back to school Monday.

Lor needs her friends to help her pass an upcoming test or face going to military school.

Tino and Tish secretly get ready for a costume party, that Lor and Carver aren't invited to.

Tino wins 2 tickets to a Chum Bukket concert and he has a tough time deciding which of his friends to take.

Lor is under pressure when she must sink three baskets in a row to win money, and thinks that losing will end her friendship with the others.

After Tino cries during Romeo and Juliet in class and is made fun of, he decides to give up all his emotions.

[3] In September 2002, the series moved to Toon Disney,[4] and new episodes began airing on October 19, 2002,[5] finishing on February 29, 2004.

[7] Due to the first-sale doctrine in the United States, the discs can be legally resold and are regularly available from sellers on eBay and other similar sites.

The Weekenders has received very positive reviews from critics and fans for its solid writing, upbeat energy and multi-dimensional characters.

In addition, Variety reported that The Weekenders took the number one rating on Saturday morning television, which knocked off Pokémon from its 54 consecutive weeks as the top spot.