It was adapted by John Dempsey (lyrics and book) and Dana P. Rowe (music), directed by Eric Schaeffer, and produced by Cameron Mackintosh.

As these powers become more sinister and events spiral out of control, the women come to realise that Darryl's influence is corrupting everyone he comes into contact with and resolve to use their new-found strength to exile him from their lives.

Starring Ian McShane in the lead role of Darryl Van Horne and Maria Friedman (Sukie), Lucie Arnaz (Alexandra) and Joanna Riding (Jane) as the three witches, the show began its preview period in London's West End on June 24, 2000 at the Theatre Royal, Drury Lane.

Ian McShane left and was replaced by his understudy, Earl Carpenter, whilst the physical production was revised to fit in the smaller theatre.

A general cast change from July 1, 2001 saw Clarke Peters lead the company, with Josefina Gabrielle and Rebecca Thornhill as Alex and Sukie respectively, joining Joanna Riding who stayed with the show after receiving the Olivier Award nomination for the role.

Starring Paul McDermott as Darryl van Horne, with Marina Prior, Angela Toohey and Pippa Grandison as Jane, Alexandra and Sukie respectively, with Sabrina Batshon, future finalist of Australian Idol season 7, as The Little Girl, and Matt Lee as Michael Spofford, the show began previews on 19 August 2002.

[3] Revisions made to the show included minor changes to lyrics, an extended dance break in 'A Little Town', and the excision of one number, 'Loose Ends'.

The premiere in the Czech Republic opened in February 2007 at the Brno City Theatre Archived 2006-09-02 at the Wayback Machine, directed by Stanislav Moša and choreographed by Igor Barberić.

It's on the technical level that [Eric Schaeffer]'s production still has kinks to work out, for until the actresses are airborne... the mechanics look and feel clunky.

Marti Pellow starred as Darryl van Horne, Ria Jones as Alexandra, Poppy Tierney as Jane and, reprising her role from the London production, Rebecca Thornhill as Sukie.

The creative team collaborated with the writers on further changes to the material, incorporating many of the rewrites from the American premiere, and making more, such as re-expanding "Eastwick Knows", adding a reprise of "Dance with the Devil" to close the exorcism scene, and reinstating "Loose Ends".

The production starred comedy actresses Maria Clara Gueiros and Fafy Siqueira as Alexandra and Felicia, respectively, and minor television actor Eduardo Galvão as Darryl.

It was a limited run and closed April 5, 2014 The show started a new season in the Syrena Theatre in the Polish capital Warsaw on March 3, 2018.

The Ogunquit Playhouse staged the American Northeast premiere of The Witches of Eastwick musical at the historic southern Maine theatre September 3–27, 2014.

Cast included James Barbour as Darryl Van Horne, Nancy Anderson as Sukie, Sara Gettelfinger as Alexandra, Mamie Parris as Jane Smart, and Sally Struthers as Felicia.

Cast included Tarrin Callendar as Daryl Van Horne, Sadie Shirley and Kiera Magurie as Alexandra Spofford, Katie Shalka and Erica Lebedeva as Jane Smart, Kirsty King and Eloise Rudkin as Sukie Rougemont, Jake Watkins and Daniel Maybury as Michael Spofford, Joseph Press as Clyde Gabriel and Eleanor Walsh as Felicia Gabriel.

[14] The concert starred John Partridge as Darryl van Horne, with Natasha J Barnes, Laura Pitt-Pulford, and Carrie Hope Fletcher as Alexandra, Jane, and Sukie respectively.

For this presentation, "A Little Town", "Eye of the Beholder", and "Who’s the Man" were restored to the score, and Maria Friedman and Carrie Hope Fletcher sung "Loose Ends" as an encore, accompanied by composer Dana P Rowe.

Prior to opening in London, a reading was held in New York on 5 March 1999 starring lyricist John Dempsey as Darryl van Horne with Sandy Duncan, Ruthie Henshall and Jacquelyn Piro Donovan as the three witches.

[15] In 2003 a staged reading took place at the Manhattan Theater Club under the direction of Gabriel Barre, starring James Barbour, Emily Skinner, Carolee Carmello and Jennifer Laura Thompson.

They talk about their boredom with their current relationships which include casual sex, abstinence and Sukie's affair with Felicia's husband, Clyde.

The teenagers are disgustingly in love with each other and the Witches, seeing how happy they are, sing about the kind of man they would like in their lives ("Make Him Mine").

The phone rings; a man from New York has arrived and bought the deserted Lenox Mansion and is tearing down the trees in his backyard.

Felicia, being the considerate soul she is, thinks of the snowy egrets that will lose their homes and decides to rally the town to stop him.

Arriving at Lenox Mansion, Darryl Van Horne emerges from a puff of smoke and begins to charm all the residents except Felicia ("I Love A Little Town").