Thelocactus multicephalus is a species of cactus endemic to Nuevo León, Mexico.

[2] Thelocactus multicephalus is a small perennial gray-green cactus that grows in clusters, growing 6 - 15 cm (5.9 in) tall and is between 8–20 cm (3.1–7.9 in) in diameter.

The areoles have 4 to 5 central spines are 1–12 cm (0.39–4.72 in) long that are grey, radial spines are absent.

Flowers, about 3–6 cm (1.2–2.4 in) long, are funnel-shaped and white and rarely light pink, growing from new growth at the top of the plant.

[3] The plant is found in Nuevo León and San Luis Potosí, Mexico growing on limestone hills at elevations between 1600 and 1700 meters Echinocactus multicephalus was first discovered near Sandia, by A. Hofer and collected by JJ.