Thelocactus tepelmemensis is a species of cactus endemic to Mexico.

Flowers, about 1.3–2.3 cm (0.51–0.91 in) long, are funnel-shaped and reddish pink with a white center, growing from new growth at the top of the plant.

[2] The plant is found in Tepelmeme, Oaxaca, Mexico growing on limestone rock at elevations between 1420 and 1460 meters.

viperina, Cnidoscolus multilobus, Fouquieria purpusii, and Agave titanota.

[2] Echinocactus tepelmemensis was first described in 2018 and named after Tepelmeme Villa de Morelos, the discovery location.